Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Pericentriolar material 1 protein (PCM1)
- Target
- PCM1
- Molecular classification
- Other (Centrosome-associated scaffolding protein), Centriolar satellite marker and scaffold
01
Overview
Pericentriolar material 1 protein (PCM1) is a 228 kDa scaffolding protein fundamental for the structure and function of centriolar satellites, which are small cytoplasmic granules involved in anchoring microtubules to the centrosome and recruiting key regulatory proteins. PCM1 is crucial for proper cell division, cilium assembly, and organization of the microtubule network. It acts as a hub for spatial recruitment of centrosomal proteins—such as centrin, pericentrin, and ninein—and for protein complexes critical to cell cycle progression and cilia formation. Genetic mutations in PCM1 are associated with increased risk of certain cancers and schizophrenia, and knockout models show a requirement for PCM1 in male fertility and ciliary motility. PCM1 is regulated by phosphorylation, polyubiquitination, and other post-translational modifications, which adjust its structural and functional contributions to centrosome biology. PCM1 is not targeted by current drugs and is used primarily in research as a marker and functional regulator of centriolar satellites and centrosome integrity.
- Other names
- PCM-1hPCM-1PTC4RET/PCM-1Pericentriolar material 1 protein
02
Biological functions
Centrosome assembly and organizationMicrotubule anchoring and dynamicsCilium biogenesisScaffold for protein localizationCell cycle progressionSpermatogenesis and ciliogenesis in multiciliated cellsProtein complex recruitment (CEP250, CETN3, PCNT, NEK2, BBSome, Tubulin polyglutamylase complex)
03
Disease associations
Cancer (papillary thyroid carcinoma, atypical chronic myeloid leukemia, T-cell lymphoma)Schizophrenia (mutation increases susceptibility)Thyroid cancer, nonmedullaryMale infertility (spermatogenesis abnormalities in knockout mice)
04
Safety considerations
Not applicable; no therapeutic targeting currently.Potential challenges for gene therapy or experimental manipulation include widespread cellular effects on division, differentiation, and cilia function
05
Biomarkers
PCM1 mutation as limited genetic risk factor in schizophreniaPCM1 involvement in chromosomal aberrations in thyroid and hematological cancers
Beyond the preview
Go deeper on Pericentriolar material 1 protein (PCM1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pericentriolar material 1 protein (PCM1).