Perilipin-2 (PLIN2)

**Perilipin-2 (PLIN2)** is a constitutively expressed, lipid droplet–associated protein and a member of the PAT family (Perilipin/ADRP/TIP47) that serves as a crucial regulator of intracellular lipid droplet formation, stability, and lipolysis[1][2][4]. It is widely present in hepatocytes, adipocytes, and macrophages, among other cell types, and facilitates triglyceride and cholesterol ester storage by binding directly to lipid droplets and controlling their turnover[2][3]. PLIN2 plays roles in lipid uptake, high-density lipoprotein (HDL)–mediated cholesterol uptake/efflux, and regulation of cellular lipid and lipoprotein profiles. Genetic variation in PLIN2 can affect systemic lipid metabolism and is implicated in metabolic diseases and certain cancers. While not a classical drug target like a receptor or enzyme, PLIN2 is nonetheless a focus of active investigation for its biomarker potential and as a candidate for therapeutically modifying lipid handling in disease states[2][4].

Other names

Adipose differentiation-related proteinADFPADRPAdipophilin

Not applicable; no approved drugs, but theoretical mechanisms would involve modulation of lipid droplet biogenesis, stability, or turnover