Perilipin-5 (PLIN5)

Perilipin-5 (PLIN5) is a member of the perilipin protein family that is primarily associated with the surface of intracellular lipid droplets, particularly in tissues with high rates of fatty acid oxidation such as heart, skeletal muscle, brown adipose tissue, and liver[1][2][3]. It plays a central role in lipid homeostasis: balancing fatty acid storage and release, shielding cells from lipotoxicity by regulating the access of lipases (enzymes that break down fat) to lipid stores, and mediating the interaction between lipid droplets and mitochondria for efficient energy metabolism[1][2]. PLIN5 expression is tightly regulated in response to metabolic demands via upstream transcription factors like PPARs, and its dysregulation is linked to various metabolic diseases, including steatosis, cardiomyopathy, metabolic syndrome, and possibly certain cancers[1][2][3]. While there are no direct drugs currently known to target PLIN5, its modulation—via drugs affecting broader lipid metabolic regulators—represents both an opportunity and a challenge in therapeutic development.

Other names

OXPATLSDP5PAT-1LSDA5MLDPLipid storage droplet protein 5OXPATperilipin 5perilipin 5

PPAR agonists increase PLIN5 expression by binding regulatory elements in the PLIN5 gene and stimulating its transcription, particularly in tissues with elevated fatty acid metabolism[2]. No direct inhibitors or pharmacological modulators of PLIN5 protein function are currently established[2].