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Perinucleolar Compartment (PNC)

Target: PNC
Molecular classification: Other

Overview

The perinucleolar compartment (PNC) is a subnuclear body located at the periphery of the nucleolus within the nucleus of eukaryotic cells. It participates in nuclear compartmentalization to organize specialized functions related to RNA metabolism within the nucleus. Its prevalence correlates strongly with malignancy and metastatic potential, making it a potential cancer marker.

Biological functions

Nuclear compartmentalizationRNA metabolism organization

Disease associations

CancerMetastasis

Biomarkers

Presence as marker for malignancy/metastasis

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