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Periocular acupuncture points

Molecular classification
Other
01

Overview

Periocular acupuncture points are specific anatomical locations situated around the orbital margin of the eye, commonly utilized in Traditional Chinese Medicine and integrative ophthalmology. These points include Jingming (BL1), Zanzhu (BL2), Sizhukong (TE23), Chengqi (ST1), Tongziliao (GB1), and the extra-channel point Yuyao (EX-HN7). Unlike conventional therapeutic targets such as receptors or enzymes, these points represent physical sites for mechanical intervention rather than molecular entities. Stimulation of these points is clinically investigated for the treatment of various ophthalmic conditions, including dry eye syndrome, myopia progression, and glaucoma, by purportedly improving ocular microcirculation and modulating neuro-endocrine pathways. Because they are anatomical sites, they do not possess a molecular structure or serve as binding sites for pharmacological drugs in the traditional sense. Research suggests their efficacy is mediated through the activation of somatosensory nerves and the subsequent release of neuropeptides that maintain ocular homeostasis.

Other names
Periorbital acupuncture pointsOcular acupuncture pointsAcupoints around the eyePeriocular acupoints
02

Mechanism of action

Stimulation of these points triggers mechanical and thermal signals that are converted into biochemical signals, modulating the autonomic nervous system and increasing retrobulbar blood flow. It is proposed to influence the expression of factors such as Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP), and regulate the secretion of tears and the stability of the tear film.

03

Biological functions

NeuromodulationRegulation of local blood flowTear film stabilizationModulation of intraocular pressureNerve stimulation
04

Disease associations

MyopiaDry eye diseaseGlaucomaOptic atrophyAge-related macular degenerationAsthenopia
05

Safety considerations

Ocular wall penetrationSubcutaneous hematomaPeriorbital bruisingLocal infectionPain at the needle site
06

Biomarkers

Tear break-up time (TBUT)Schirmer test scoreIntraocular pressure (IOP)Visual acuityOphthalmic artery blood flow velocity

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