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Target intelligence / Profile preview
Periodic tryptophan protein 1 homolog (PWP1)
- Target
- PWP1
- Molecular classification
- chromatin-associated factor, nuclear phosphoprotein, WD-40 repeat protein
01
Overview
Periodic tryptophan protein 1 homolog (PWP1) is a nuclear, chromatin-associated protein characterized by WD-40 repeats that regulate transcriptional processes. It is integral to rRNA biogenesis mediated by RNA polymerase I, controls the epigenetic status of ribosomal DNA, and is implicated in the regulation of cell cycle–dependent transcriptional events. PWP1 expression is upregulated in certain cancers, including pancreatic adenocarcinoma, and is associated with disease such as adenocarcinoma and porokeratosis. PWP1 is not currently classified as a receptor, enzyme, or therapeutic target and has no approved interacting drugs, mechanisms of drug action, or established biomarker or safety roles[2][6][8][4][3].
- Other names
- endonucleinIEF-SSP-9502nuclear phosphoprotein similar to S. cerevisiae PWP1keratinocyte protein IEF SSP 9502NCLB2310058A11Rik2610205J09Rik
02
Biological functions
Regulates transcriptionPol I-mediated rRNA biogenesisepigenetic status of rDNApositive regulation of stem cell differentiationhistone H4-K20 trimethylationnegative regulation of peptidyl-serine phosphorylation
03
Disease associations
Canceradenocarcinomapancreatic adenocarcinomahead and neck squamous cell carcinomaPorokeratosis
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