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Periodic tryptophan protein 2 homolog (PWP2)
- Target
- PWP2
- Molecular classification
- Ribosome biogenesis factor, WD repeat domain-containing protein, Nucleolar protein, Small subunit processome component
01
Overview
Periodic tryptophan protein 2 homolog (PWP2) is a conserved, nucleolar protein that is an essential component of the small subunit (SSU) processome, the primary precursor of the small eukaryotic ribosomal subunit. PWP2 functions within the UtpB subcomplex and plays a central role in the biogenesis and assembly of the 18S rRNA-containing small ribosomal subunit by facilitating rRNA folding, modification, and processing events. It is classified as a WD-repeat-containing protein, which enables interactions with RNA and numerous protein partners within the nucleolus. Genetic disruption of PWP2 affects ribosome assembly and leads to cellular and developmental defects. No current drugs are known to target PWP2, and it is not considered a therapeutic target as of 2025.
- Other names
- EHOC-17PWP2HUTP1small subunit processome componentPWP2 periodic tryptophan protein homolog (yeast)UTPB SSU processome subunit
02
Mechanism of action
Not applicable; PWP2 is not an established therapeutic target
03
Biological functions
Ribosomal small subunit biogenesisAssembly of small subunit processomeRNA bindingPart of the rRNA processing pathwayInvolved in nucleolar ribonucleoprotein complex formation
04
Disease associations
Holoprosencephaly 1Carpal tunnel syndrome 2No direct role in cancer, inflammation, or other major diseases established as of now
05
Safety considerations
None reported in the context of therapeuticsPotential developmental impact via ribosome biogenesis
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