Peripheral nerve ending in skin

Nerves in the skin" is not a single molecular entity or therapeutic target, but refers collectively to the network of peripheral nerve endings that innervate the skin. These include terminals of sensory neurons responsible for different modalities such as touch, pain, itch, and temperature (mechanoreceptors, nociceptors, thermoceptors)[1][2][3]. These nerves form a dense and complex system, play essential roles in the neuro-immuno-cutaneous system, and interact with skin cells via neuropeptides, cytokines, and various signaling molecules[1][2]. Dysfunction or damage of these nerves is central to conditions like peripheral neuropathy and chronic pain, but "nerves in the skin" does not correspond to a canonical drug target, molecule, enzyme, or receptor, making it an incorrect target in the sense required for drug discovery or pharmacological intervention[1][3][5].

Other names

Cutaneous nervesSensory nerves of the skinSkin nerve fibers