Peripheral nerve fiber

A peripheral nerve fiber is the axonal or dendritic extension of a neuron within a nerve of the peripheral nervous system (PNS), bundled with other fibers and surrounded by connective tissue sheaths (endoneurium, perineurium, epineurium)[1][2][5]. Peripheral nerve fibers can be sensory (afferent), motor (efferent), or autonomic. They are categorized by structure (myelinated A fibers, thinly myelinated B fibers, unmyelinated C fibers) and function (conduction velocity, receptor/type served)[2][6]. Peripheral nerve fibers transmit electrical signals between the central nervous system and body tissues and are affected in conditions such as neuropathies, trauma, and pain syndromes[7][9]. Key clarification: "Peripheral nerve fiber" is not a receptor, enzyme, transporter, or similar molecular target, but rather a general anatomical structure comprising various axons. It does not have therapeutic selectivity as a single molecular entity, nor does it have a canonical abbreviation or singular molecular classification. This term may be too broad for drug target databases or therapeutic development frameworks that require a discrete molecular entity.

Other names

Nerve fiberaxon (in context)peripheral axonperipheral nerve axon

Sodium channel blockade (local anesthetics) Axonal transport inhibition (some toxins/drugs)