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Peripheral Nerve Schwann Cell (SC)

Target: SC
Molecular classification: Glial Cell

Overview

Peripheral nerve Schwann cells are a specialized type of glial cell found exclusively in the peripheral nervous system (PNS). They play essential roles in the development, maintenance, function, and regeneration of peripheral nerves. Schwann cells surround neurons and can either myelinate axons—forming insulating layers that speed up nerve impulse conduction—or remain non-myelinating, supporting smaller caliber axons within structures called Remak bundles.

Other names: Schwann CellSCsNeurolemmocyte

Biological functions

MyelinationNeuronal SupportNerve RegenerationAxon guidancePhagocytosisSecretion of extracellular matrixExpression of adhesion molecules

Disease associations

Neuropathies (inflammatory, metabolic, hereditary)Nerve InjuryHIV-associated distal sensory polyneuropathy

Safety considerations

Immune rejection (in transplantation)Challenges in controlling differentiation and proliferation

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