Target intelligence / Profile preview

Peristalsis stimulation via increased fecal mass

Molecular classification
Other
01

Overview

"Peristalsis stimulation via increased fecal mass" refers to the initiation or enhancement of peristaltic contractions in the gastrointestinal tract as a response to increased volume or bulk of intestinal contents. This increased mass stretches the walls of the colon and rectum, activating stretch-sensitive enteric nerves and triggering the peristaltic reflex, which propels fecal material toward the anus, facilitating defecation[3][5][7]. Clinically, this mechanism underlies the action of many bulk-forming or osmotic laxatives used to manage constipation.

Other names
Increased fecal bulkIncreased stool massBulk-mediated peristalsis
02

Mechanism of action

Increases fecal mass, stimulating stretch receptors in the colonic wall, which in turn triggers peristaltic reflexes via the enteric nervous system, promoting bowel movement[3][4][5][7][9].

03

Biological functions

Gastrointestinal motilityPeristalsisDefecation reflex
04

Disease associations

ConstipationChronic idiopathic constipationIrritable bowel syndrome with constipation (IBS-C)Other
05

Safety considerations

BloatingAbdominal discomfortFlatulenceRisk of intestinal obstruction with excessive bulk (rare)
06

Interacting drugs

Psyllium (soluble fiber)

5 more in the full profile.

07

Biomarkers

Stool frequencyFecal bulk/weightColonic transit time

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