Peritoneal Membrane Biocompatibility Enhancement

Peritoneal membrane biocompatibility enhancement refers to strategies and interventions aimed at preserving or improving the structural and functional integrity of the peritoneal membrane during peritoneal dialysis (PD). The goal is to minimize damage caused by conventional PD solutions, which can induce fibrosis, inflammation, and loss of mesothelial cell function over time. Enhancing biocompatibility is critical for maintaining effective dialysis, reducing complications such as peritonitis and ultrafiltration failure, and prolonging the viability of PD as a renal replacement therapy. This target does not refer to a single molecule/receptor but rather encompasses multiple biochemical targets/pathways involved in maintaining healthy peritoneal tissue during chronic dialysis therapy.

Multiple: Reduction of glucose/GDP-induced injury, modulation of oxidative/inflammatory pathways, preservation of mesothelial cell function.