Peroxidasin (PXDN)

Peroxidasin (PXDN) is a multidomain, heme-containing peroxidase enzyme that catalyzes the cross-linking of collagen IV molecules in basement membranes, crucial for providing mechanical stability to tissues during development, homeostasis, and repair. PXDN processes hydrogen peroxide and halides to generate hypohalous acids, particularly hypobromous acid, which drives the formation of unique sulfilimine bonds between collagen IV monomers and stabilizes extracellular matrix structure. PXDN is highly glycosylated and secreted primarily as a homotrimer. In addition to its structural role, PXDN participates in host defense through oxidative protein cross-linking, and its dysregulation has been implicated in cancer progression, fibrosis, vascular remodeling, and inherited basement membrane disorders such as congenital eye defects. Select inhibitors such as ABAH block its peroxidase activity in vitro, but no approved drugs selectively target PXDN in clinical medicine as of 2025.

Other names

Peroxidasin homologPXDN active fragmentKIAA0230MG50PRG2PXD01VPOVPO1hsPxd01D2S448D2S448EPXNMelanoma-associated antigen MG50Peroxidasin 1Vascular peroxidase 1p53-responsive gene 2 proteinASGD7COPOA

Inhibition of peroxidase activity (e.g., via compounds like ABAH). Hypothetical: Blockade of collagen IV cross-linking by targeting peroxidase or Ig domains (theoretical, not established clinically).