Target intelligence / Profile preview

Peroxiredoxin 3 (None specified)

Target: None specified
Molecular classification: Enzyme, Peroxiredoxin family of antioxidant enzymes, Thiol-specific peroxidase

Overview

Peroxiredoxin 3 is an essential mitochondrial antioxidant enzyme involved not only in detoxifying ROS but also regulating cell fate decisions under both physiological conditions and disease states such as cancer, metabolic syndrome, inflammation, and drug-induced organ injury.

Other names: PRDX3HsPrx3

Mechanism of action

The active site cysteine reacts with hydrogen peroxide/peroxide substrates forming sulfenic acid. This intermediate forms an intermolecular disulfide bond with another conserved cysteine on an adjacent subunit. Thioredoxin reduces this disulfide bond back to free thiols, completing the catalytic cycle

Biological functions

Antioxidant activityRedox homeostasisRegulation of cellular proliferationRegulation of cellular differentiationScavenging reactive oxygen species (ROS)

Disease associations

CancerHepatocellular carcinomaBreast cancerProstate cancerMetabolic disordersObesityInflammationDrug-induced liver injury

Safety considerations

Overexpression confers resistance against chemotherapeutic agentsPotential target for sensitizing tumors during treatment regimens

Interacting drugs

Doxorubicin

1 more in the full profile.

Biomarkers

Serum PRDX3 (Hepatocellular carcinoma diagnosis/assessment)

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