Peroxiredoxin 3 pseudogene 3 (PRDX3P3)

Peroxiredoxin 3 pseudogene 3 (PRDX3P3) is a segment of DNA in the human genome that shares high sequence similarity to the functional peroxiredoxin 3 (PRDX3) gene but lacks the necessary regulatory sequences or coding potential to produce a functional protein[2]. Pseudogenes such as PRDX3P3 typically arise by gene duplication or reverse transcription events and accumulate disabling mutations (frameshifts, premature stop codons) that prevent protein formation. While rare pseudogenes may contribute to gene regulation (e.g., through their RNA), PRDX3P3 has no reported biological function or relevance as a therapeutic target. It should not be confused with the functional PRDX3 gene, which is an antioxidant enzyme involved in mitochondrial redox regulation and has potential relevance in cancer and cell proliferation[1]. Pseudogenes can complicate genetic studies and may be incorrectly annotated in genome databases[2]. PRDX3P3 is best classified as a noncoding, nonfunctional pseudogene, and inclusion as a therapeutic target, receptor, enzyme, etc., is incorrect.

Other names

PRDX3P3