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Target intelligence / Profile preview
Peroxiredoxin 6 (PRDX6)
- Target
- PRDX6
- Molecular classification
- Enzyme, Peroxiredoxin family, Glutathione peroxidase, Phospholipase A2, LPCAT
01
Overview
Peroxiredoxin 6 (PRDX6) is a bifunctional antioxidant enzyme with glutathione peroxidase and phospholipase A2 activities. It protects cells from oxidative damage by reducing hydroperoxides and repairing oxidized cell membranes. It is implicated in various diseases related to oxidative stress.
- Other names
- 1-Cys PeroxiredoxinNon-selenium glutathione peroxidaseAntioxidant enzymeCalcium-independent phospholipase A2
02
Mechanism of action
Inhibition or activation of PRDX6 enzymatic activities (glutathione peroxidase, PLA2, LPCAT)
03
Biological functions
Antioxidant defenseRedox regulationPhospholipid metabolismMembrane repairSurfactant metabolismRedox signalingNADPH oxidase activation
04
Disease associations
Acute lung injuryNeurodegenerationCancer progressionCancer metastasisOxidative stress-related diseases
05
Safety considerations
Potential for disruption of phospholipid homeostasisUnintended consequences of modulating redox signalingOff-target effects on other peroxidase or phospholipase activities
06
Biomarkers
PRDX6 expression levels in tissue or serum as a marker of oxidative stress or disease progression
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