Peroxiredoxin I (PRDX1)

Peroxiredoxin I (PRDX1) is an abundant, highly conserved cysteine-dependent peroxidase enzyme and key member of the peroxiredoxin family. It reduces hydrogen peroxide, organic hydroperoxides, and peroxynitrite to protect cells from oxidative damage and regulate redox balance. PRDX1 is involved in cell signaling, especially in modulating peroxide-mediated signal transduction, and plays roles in cell differentiation, proliferation, and stress response. Dysregulation or altered expression of PRDX1 has important implications in cancer biology, inflammation, cardiovascular and neurodegenerative diseases. In addition to classical peroxidase activity, PRDX1 can function as a disulfide reductase, influencing processes such as motor neuron differentiation through interaction with proteins like GDE2.

Other names

PRDX1Prx IPeroxiredoxin-1

Reduction of peroxides and ROS (reactive oxygen species) via cysteine-dependent mechanisms. Regulatory modulation of cell signaling by oxidation state transfer to effector proteins. Disulfide reductase activity for other protein targets (e.g. GDE2).