Peroxiredoxin like 2B (PRXL2B)

Peroxiredoxin like 2B (PRXL2B) is a human protein encoded by the PRXL2B gene, acting as a prostamide/prostaglandin F synthase and member of the peroxiredoxin family[5]. It catalyzes the NADPH-dependent reduction of prostaglandin-ethanolamide H2 (prostamide H2) to prostamide F2alpha, and also reduces prostaglandin H2 to prostaglandin F2alpha[2][6]. The protein exhibits antioxidant activity by reducing hydrogen peroxide and organic hydroperoxides, thus playing a role in cell protection from oxidative damage[3][8]. PRXL2B is implicated in the biosynthesis of prostaglandins and prostamides and is involved in the regulation of intraocular pressure, as deleting its gene in mice leads to elevated eye pressure, suggesting a potential role in conditions like glaucoma[4]. PRXL2B localizes to the mitochondrion and extracellular exosomes[1][2], and ongoing research is elucidating its broader biological and pathological significance. If you require structured data extraction or further breakdowns, more detailed pathway/drug/biomarker listings may require additional targeted pharmacological data.

Other names

Prostamide/prostaglandin F synthaseC1orf93FAM213BFamily with sequence similarity 213 member BProtein FAM213BThioredoxin-type PGF synthase

Catalyzes reduction of prostaglandin-ethanolamide H(2) (prostamide H2) to prostamide F(2alpha) using NADPH; Reduces prostaglandin H2 to prostaglandin F(2alpha); Functions as a thioredoxin peroxidase