Target intelligence / Profile preview

Peroxiredoxin-Thioredoxin System (Prx-Trx System)

Target: Prx-Trx System
Molecular classification: Enzyme System, Antioxidant System, Redox Signaling System

Overview

The peroxiredoxin-thioredoxin system is a central cellular antioxidant and redox signaling network. It consists primarily of peroxiredoxins (Prxs), thioredoxin (Trx), and thioredoxin reductase (TrxR). This system plays a crucial role in detoxifying reactive oxygen species (ROS) such as hydrogen peroxide, maintaining redox homeostasis, and regulating redox-dependent signaling pathways in cells. Dysfunction or imbalance is implicated in various diseases including diabetes mellitus, cancer progression, neurodegeneration, inflammation, and cardiovascular disorders.

Other names: Prx/Trx SystemThioredoxin SystemPeroxiredoxin System

Mechanism of action

N/A

Biological functions

Antioxidant DefenseRedox SignalingCellular HomeostasisROS detoxificationRegulation of redox-dependent signaling

Disease associations

Diabetes MellitusCancer ProgressionNeurodegenerationInflammationCardiovascular DisordersOxidative Stress-related Diseases

Beyond the preview

Go deeper on Peroxiredoxin-Thioredoxin System (Prx-Trx System).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Peroxiredoxin-Thioredoxin System (Prx-Trx System).

Explore the full profile