Peroxisomal fatty acid beta-oxidation enzyme (None universally accepted; individual enzymes have canonical abbreviations (e.g., ACOX1 for acyl-CoA oxidase))

Peroxisomal fatty acid beta-oxidation enzymes are a group of enzymes localized in the peroxisome, responsible for the breakdown of very long-chain and branched-chain fatty acids. The process involves multiple enzymatic steps—first, acyl-CoA oxidase oxidizes fatty acyl-CoA substrates, producing hydrogen peroxide. Multifunctional proteins (MFPs) then hydrate and dehydrogenate the substrate, and finally thiolases cleave acetyl-CoA units, progressively shortening the fatty acid chain. This metabolic pathway is critical for energy homeostasis, lipid detoxification, myelin synthesis, and cellular maintenance. Deficiency or dysfunction of these enzymes results in serious metabolic diseases, often with severe neurological and systemic manifestations. The term "Peroxisomal fatty acid beta-oxidation enzyme" refers to a family/class of enzymes rather than a specific protein or receptor. To be structurally precise, the canonical form should specify the individual enzyme (e.g., "Peroxisomal acyl-CoA oxidase") for structured data or drug discovery programs.

Other names

Peroxisomal beta-oxidation enzymesperoxisomal acyl-CoA oxidaseperoxisomal MFP (multifunctional protein)peroxisomal thiolase

Not drug-targeted directly; disease management typically involves bypassing defective metabolism, dietary controls, or supporting residual function