Peroxisomal membrane protein 11B (PEX11B)

Peroxisomal membrane protein 11B (PEX11B) is a transmembrane protein encoded by the PEX11B gene in humans and is essential for peroxisome proliferation and division. It remodels and elongates peroxisome membranes by interacting with specific membrane lipids through its N-terminal amphipathic helices, then assembles and activates multiple division factors, specifically FIS1, MFF, and DRP1. PEX11B can promote peroxisome division even in the absence of MFF, functioning in a FIS1- and DRP1-dependent manner, and can also impact mitochondrial dynamics if targeted to mitochondria. Mutations lead to rare, inherited peroxisomal biogenesis disorders with neurological and developmental phenotypes. PEX11B is found in the peroxisomal membrane and interacts with proteins such as PEX19 for membrane insertion

Other names

PEX11BPEX11-betaPEX11βPeroxisomal biogenesis factor 11 betaPeroxisomal membrane protein 11BProtein PEX11 homolog betaPeroxin-11BPEX11-BETAPEX11betaPEX14B

Not applicable. No direct drug mechanism; however, research suggests upregulating PEX11B or MFF might restore peroxisome dynamics in disease, a concept still in preclinical investigation