Peroxisomal membrane protein 14 (PEX14)

Peroxisomal membrane protein 14 (PEX14) is an essential integral membrane protein of peroxisomes, crucial for peroxisomal protein import and biogenesis. It serves as a central docking site for soluble receptor proteins, primarily PEX5 and PEX7, which mediate the delivery of matrix proteins carrying peroxisomal targeting signals (PTS1 and PTS2)[1][2][3][4][6]. The C-terminus of PEX14 is exposed to the cytosol, facilitating interaction with cytosolic trafficking factors. PEX14 also has a role as a transcriptional corepressor by interacting with histone deacetylases[1]. Mutations in PEX14 can cause peroxisome biogenesis disorders, such as Zellweger syndrome, characterized by severe neurological and metabolic abnormalities[1][6]. Structurally, PEX14 contains domains necessary for membrane integration and specific interaction motifs that enable competitive binding with PEX5 and PEX19, key proteins in peroxisome assembly and maintenance[3][4][7]. PEX14 is indispensable for both the import of new proteins and for pexophagy, thus balancing peroxisome formation and turnover[2][5]. Interactions with other peroxins include PEX13 and potentially PEX19, emphasizing its central role in peroxisome dynamics and cellular metabolism[1][3][4].

Other names

PEX14Peroxisomal biogenesis factor 14Pex14pPeroxisomal membrane anchor protein PEX14PTS1 receptor-docking proteinPeroxin-14NAPP2PBD13AdJ734G22.2NF-E2 associated polypeptide 2