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Peroxisomal membrane protein 2 (PXMP2)

Target: PXMP2
Molecular classification: Integral membrane protein, Other (pore-forming channel)

Overview

Peroxisomal membrane protein 2 (PXMP2) is an integral membrane protein in the peroxisomal membrane that forms non-selective aqueous channels for small solute diffusion. It restricts passage of larger metabolites and is essential for peroxisomal metabolic compartmentalization and solute exchange. PXMP2 is highly expressed in peroxisome-rich tissues and, while dispensable for hydrogen peroxide flux under normal conditions, contributes to overall membrane permeability and function[2][1][3].

Other names: PMP22MPV17L322 kDa peroxisomal membrane proteinPXMP2

Biological functions

Non-selective pore formationFacilitates diffusion of small solutes

Disease associations

Other (minor metabolic phenotype in knockout models)

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