Peroxisomal membrane protein PEX16 (PEX16)

Peroxisomal membrane protein PEX16 is an integral peroxisomal membrane protein involved in the biogenesis and maintenance of peroxisomes, cellular organelles essential for lipid metabolism and detoxification of reactive oxygen species. PEX16 plays a central role by targeting and recruiting other peroxisomal membrane proteins, such as PEX3, to the endoplasmic reticulum and mature peroxisomes, thus facilitating the formation of new peroxisomes and supporting their proliferation and maintenance in mammals and plants[1][2][3]. Loss-of-function mutations in PEX16 are associated with peroxisomal biogenesis disorders, including Zellweger spectrum disorders[3]. Alternative splicing and varied localization in different species (including plants and yeasts) underlie diversity in its cellular roles, but the core function in membrane protein targeting and peroxisome formation is highly conserved[1][2][3]. If further structured information, such as specific drug interactions or biomarker roles for PEX16 exists, it is not provided in current biomedical databases or literature as of the cited sources.

Other names

Peroxisomal biogenesis factor 16Peroxin-16PBD8APBD8Bperoxin 16