Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Peroxisome assembly factor 2 (PEX6)
- Target
- PEX6
- Molecular classification
- Enzyme, AAA+ ATPase, Peroxin, Organelle biogenesis factor
01
Overview
Peroxisome assembly factor 2 (PEX6) is an AAA+ ATPase enzyme that forms a hexameric complex with PEX1; together, they are essential for peroxisome biogenesis by recycling the peroxisomal import receptor PEX5 from the peroxisomal membrane, enabling repeated rounds of matrix protein import. PEX6 is recruited to the peroxisome membrane via PEX26 and is crucial for maintaining peroxisomal function across eukaryotes. Mutations in PEX6 are a leading genetic cause of peroxisomal biogenesis disorders, such as Zellweger syndrome spectrum, indicating its critical role in cellular metabolism and development[1][2][3][4].
- Other names
- Peroxisomal biogenesis factor 6Peroxisomal ATPase PEX6Peroxin-6Peroxisomal-type ATPase 1Peroxisome assembly factor 2PXAAA1PAF-2PBD4APDB4Bperoxisomal AAA-type ATPase 1
02
Biological functions
Peroxisome biogenesisPeroxisomal protein importOrganelle maintenanceProtein unfolding and extractionOrganelle homeostasis
03
Disease associations
Peroxisomal biogenesis disordersZellweger spectrum disorderInfantile Refsum diseaseNeonatal adrenoleukodystrophyOther peroxisome-related metabolic diseases
Beyond the preview
Go deeper on Peroxisome assembly factor 2 (PEX6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Peroxisome assembly factor 2 (PEX6).