Peroxisome proliferator–activated receptor delta (PPARδ)

Peroxisome proliferator–activated receptor delta (PPARδ) is a nuclear hormone receptor that functions as a ligand-dependent transcription factor. It regulates genes involved in lipid and glucose metabolism, cellular differentiation, inflammation, and other processes. Activated by fatty acids and eicosanoids, it forms heterodimers with RXRs to bind PPREs and modulate gene expression. PPARδ plays roles in metabolic regulation, cardiovascular function, and potentially cancer, with studies showing conflicting evidence for its role in tumor progression.

Other names

PPAR-deltaPPARβPPAR-betaNUC1Nuclear hormone receptor 1PPARD

Upon ligand binding, PPARδ forms heterodimers with retinoid X receptors (RXRs). This complex binds to specific DNA sequences called peroxisome-proliferator response elements (PPREs) within target gene promoters to regulate transcription.