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Target intelligence / Profile preview
Peroxisome proliferator-activated receptor alpha (PPARα)
- Target
- PPARα
- Molecular classification
- Transcription factor, Nuclear receptor
01
Overview
Peroxisome proliferator-activated receptor alpha (PPARα), also known as NR1C1, is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. It plays a central role in regulating lipid metabolism, energy homeostasis, inflammation, and vascular biology.
- Other names
- NR1C1Nuclear receptor subfamily 1, group C, member 1
02
Mechanism of action
Agonists bind to PPARα, forming heterodimers with RXR, and bind to PPREs to regulate transcription of target genes involved in lipid metabolism, inflammation, and other processes.
03
Biological functions
Lipid metabolismEnergy homeostasisInflammationVascular biologyCell proliferationCell differentiation
04
Disease associations
HyperlipidemiaNon-alcoholic fatty liver disease (NAFLD)Type 2 diabetes mellitusCardiovascular diseasesCancerMetabolic Syndrome
05
Interacting drugs
Fibrate drugs
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