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Target intelligence / Profile preview
Peroxisome proliferator-activated receptor delta (PPAR-delta)
- Target
- PPAR-delta
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
Peroxisome proliferator-activated receptor delta (PPAR-delta) is a nuclear receptor encoded by the PPARD gene in humans. It functions as a ligand-activated transcription factor that plays a key role in energy metabolism, particularly in adipose tissues. PPAR-delta represents an important therapeutic target with diverse biological functions and potential applications in treating metabolic disorders, though its complex role in cancer biology requires careful consideration when developing targeted therapies.
- Other names
- PPAR-betaNuclear hormone receptor 1 (NUC1)NUCI
02
Mechanism of action
PPAR-delta activates transcription of various target genes by binding to specific DNA elements. As a nuclear receptor, it binds peroxisome proliferators and other ligands to regulate gene expression.
03
Biological functions
Lipid metabolismGlucose metabolismMuscle functionCell differentiationCell migrationMyelinationTranscription regulation
04
Disease associations
DiabetesObesityAtherosclerosisCancerMetabolic disorders
05
Safety considerations
Potential link to cancer progression (tumor angiogenesis)
06
Interacting drugs
Bezafibrate
1 more in the full profile.
07
Biomarkers
PDK4ANGPTL4PLIN2CD36
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