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Target intelligence / Profile preview
Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)
- Target
- PPARγ
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and ligand-activated transcription factor that regulates genes involved in adipogenesis, lipid metabolism, glucose homeostasis, insulin sensitivity, and inflammation. It plays a central role in energy balance and metabolism and is a therapeutic target for type 2 diabetes.
- Other names
- PPAR-gammaPPARGNR1C3Nuclear receptor subfamily 1 group C member 3glitazone reverse insulin resistance receptor
02
Mechanism of action
Forms heterodimers with RXRs, binds to PPREs on DNA, recruits coactivators or corepressors to modulate gene transcription involved in energy balance and metabolism. Synthetic agonists like thiazolidinediones improve insulin sensitivity by activating PPARγ-mediated gene programs.
03
Biological functions
Adipocyte differentiationLipid uptakeLipid storageLipid metabolismGlucose homeostasisInsulin sensitivityInflammation controlFluid homeostasisGene regulation
04
Disease associations
Type 2 diabetesCardiovascular diseaseCancerInflammatory disordersMetabolic diseases
05
Safety considerations
Dysregulation or mutation implicated in metabolic diseases, cardiovascular disease, cancer, and inflammatory disorders.Phosphorylation at serine 112 inhibits function and affects insulin sensitivity.
06
Interacting drugs
Rosiglitazone
2 more in the full profile.
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