Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)

Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B) is a protein that acts as a transcriptional coactivator for a range of nuclear receptors and transcription factors, notably including PPARs, estrogen receptor alpha, nuclear respiratory factor 1 (NRF1), and the glucocorticoid receptor[1][2]. PPARGC1B plays key roles in regulating energy metabolism, mitochondrial biogenesis, fatty acid and glucose oxidation, and the modulation of genes involved in oxidative phosphorylation and metabolic homeostasis[1][2][3]. It is highly expressed in tissues with substantial energy requirements, such as heart, skeletal muscle, and brain[3]. PPARGC1B has been implicated in several disease contexts, notably metabolic disorders (like obesity and diabetes), cardiovascular conditions, cancer, and neurological diseases, often through its role in mitochondrial function and systemic energy metabolism[1][2]. While it is increasingly recognized as a promising therapeutic target due to its pivotal role in cellular energetics, direct pharmacological modulators have not yet advanced to clinical practice, and the complexity of its action necessitates careful therapeutic exploration[2].

Other names

PGC-1-betaPGC1BPPARGC1BPPAR-gamma coactivator 1-betaPeroxisome proliferator-activated receptor gamma coactivator 1-betaPGC-1(beta)PGC1ERRL1PERCPPARgamma coactivator 1 betaPGC-1-related estrogen receptor alpha coactivatorPPARGC-1-betaPPARAGCIβPPARAGCIbeta

No direct small-molecule drugs are clinically approved; modulation of activity affects transcriptional regulation of metabolic and mitochondrial genes, chiefly by coactivating nuclear receptors (PPARs, ERRs, NRFs, estrogen receptor, glucocorticoid receptor)[1][2].