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Peroxynitrite (None)
- Target
- None
- Molecular classification
- Reactive Nitrogen Species, Oxidant
01
Overview
Peroxynitrite (ONOO⁻) is a potent oxidant and nitrating agent formed by the reaction of nitric oxide and superoxide. It reacts with biomolecules, causing cellular damage through lipid peroxidation, protein tyrosine nitration, DNA strand breaks, and mitochondrial dysfunction. Peroxynitrite is implicated in various disease processes, including inflammation, atherosclerosis, neurodegenerative diseases, and cardiovascular disorders.
- Other names
- Oxido nitritePeroxonitrite ionOxoperoxonitrate(1-)ONOO⁻
02
Biological functions
OxidationNitrationCell death inductionImmune response
03
Disease associations
InflammationAtherosclerosisNeurodegenerative diseasesCardiovascular disorders
04
Safety considerations
Cellular damage due to lipid peroxidationProtein tyrosine nitrationDNA strand breaks or base modificationsMitochondrial dysfunction
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