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Pertussis Antigen (N/A)
- Target
- N/A
- Molecular classification
- Exotoxin, Adhesion protein, Surface antigen
01
Overview
Pertussis antigens are molecular components derived from the bacterium *Bordetella pertussis*, the causative agent of whooping cough (pertussis). These antigens are used in vaccines and diagnostic assays to elicit or detect immune responses against the pathogen. Key antigens include Pertussis Toxin (PT), Filamentous Hemagglutinin (FHA), and Pertactin (PRN). Antibodies generated against these antigens can neutralize bacterial toxins, block adherence mechanisms, promote opsonophagocytosis, and facilitate clearance by the immune system. Modern acellular pertussis vaccines contain purified forms of these antigens to induce protective immunity while minimizing reactogenicity.
- Other names
- Pertussis ToxinFilamentous HemagglutininPertactinFimbriae
02
Mechanism of action
N/A
03
Biological functions
Adhesion to host tissuesImmune evasionAntigen presentationInduction of neutralizing antibodies
04
Disease associations
InfectionWhooping cough (Pertussis)
05
Safety considerations
Reactogenicity of whole-cell vaccinesPotential for antigen loss due to vaccine pressure
06
Interacting drugs
N/A
07
Biomarkers
Anti-PT antibodiesAnti-FHA antibodiesAnti-PRN antibodies
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