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Target intelligence / Profile preview
Bordetella pertussis Antigens (B. pertussis Antigens)
- Target
- B. pertussis Antigens
- Molecular classification
- Exotoxin, Surface protein, Outer membrane protein, Fimbrial protein, Adhesin, Protein
01
Overview
Bordetella pertussis antigens are bacterial components that elicit immune responses in the host. Key antigens include Pertussis Toxin (PT), Filamentous Hemagglutinin (FHA), Pertactin (PRN), and Fimbriae (Fim2/Fim3). These antigens are crucial for bacterial adhesion, colonization, and virulence. They are also the main components of acellular pertussis vaccines, designed to induce protective immunity.
- Other names
- Pertussis antigensWhooping cough antigens
02
Mechanism of action
Vaccines induce antibody and T-cell responses against the antigens, preventing or mitigating infection.
03
Biological functions
AdhesionColonizationImmune modulationToxin activityVirulenceAntigen presentation
04
Disease associations
InfectionWhooping coughRespiratory disease
05
Safety considerations
Vaccine reactogenicity (historical whole-cell vaccines)Waning immunity post-vaccinationAntigenic variability
06
Interacting drugs
Pertussis vaccines (acellular)
1 more in the full profile.
07
Biomarkers
Anti-PT IgGAnti-FHA IgGAnti-PRN IgGAnti-FIM IgG
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