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Target intelligence / Profile preview
Pescadillo ribosomal biogenesis factor 1 (PES1)
- Target
- PES1
- Molecular classification
- Nucleolar protein, Ribosome biogenesis factor, Ribosomal maturation factor, Ribonucleoprotein complex protein
01
Overview
Pescadillo ribosomal biogenesis factor 1 (PES1) is a nucleolar protein essential for ribosome biogenesis, as part of the PeBoW complex (with BOP1 and WDR12), required for processing precursor rRNA and maturation of the 60S ribosomal subunit. It also regulates cell cycle progression, DNA replication, telomerase assembly, and cellular senescence. PES1 is overexpressed in various cancers and promotes oncogenic growth by modulating cell cycle regulators and estrogen receptor signaling, and by enhancing cancer stem cell characteristics. Its depletion impairs ribosome production and increases sensitivity to chemotherapy. PES1 is a promising molecular target but presents safety concerns due to its central role in normal cellular proliferation.
- Other names
- Pescadillo homologPESNOP7pescadillo homolog 1, containing BRCT domainPeBoW complex protein
02
Mechanism of action
Theoretical mechanisms include suppression or depletion of PES1 resulting in impaired ribosome biogenesis, cell cycle arrest, increased chemosensitivity, and inhibition of telomerase activity; modulation affecting estrogen signaling and ERα/ERβ ratio in hormone-dependent cancers
03
Biological functions
Ribosome biogenesispre-rRNA processing60S ribosomal subunit maturationCell cycle progressionCell proliferationDNA replication (S phase entry)Telomerase assemblyGenomic integrity
04
Disease associations
Cancer (breast, ovarian, colon, gastric, hepatocellular, pancreatic, prostate, head and neck squamous cell carcinomas)TumorigenesisChemoresistanceMetabolic dysregulation (obesity-linked hepatic dysfunction)
05
Safety considerations
Therapeutic targeting is challenged by PES1’s essential roles in normal cell proliferation and ribosome formation, raising risks for hematopoietic or gastrointestinal toxicity, impaired DNA repair, and effects on nonmalignant dividing cells
06
Interacting drugs
No specific drugs directly targeting PES1 are currently approved or in clinical use; experimental data may exist for compounds modulating PES1 expression in cell models
07
Biomarkers
Elevated PES1 expression may serve as a biomarker of poor prognosis and aggressive tumor behavior in multiple cancers
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