Peter pan homolog (PPAN)

Peter pan homolog (PPAN) is an evolutionarily conserved protein in humans encoded by the PPAN gene, with homology to yeast SSF1 and the Drosophila Peter Pan gene[1][3][10]. PPAN is essential for cell growth and proliferation and participates in ribosome biogenesis as a Brix domain-containing protein. It is involved in mRNA splicing (especially the second step), mitochondrial homeostasis (through modulation of autophagy), and regulation of apoptosis[1]. Depletion of PPAN leads to increased apoptosis, cell cycle arrest, and upregulation of p53 and its targets. The gene has ubiquitous expression, and its exogenous expression can reduce the anchorage-independent growth of certain tumor cells. Disease association has been noted with narcolepsy and cancer, reflecting its importance in cellular proliferation and differentiation[7][1][10]. There are currently no known drugs, biomarkers, or direct safety considerations linked to therapeutic targeting of PPAN.

Other names

Suppressor of SWI4 1 homologBXDC3SSF1SSF2SSFBrix domain-containing protein 3second-step splicing factor 1suppressor of sterile four 1homolog of S. cerevisiae SSF1