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PEX5L antisense RNA 2 (PEX5L-AS2)

Target
PEX5L-AS2
Molecular classification
Long non-coding RNA (lncRNA), Antisense RNA, Non-protein coding RNA
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Overview

PEX5L antisense RNA 2 (PEX5L-AS2) is a long non-coding RNA (lncRNA) transcribed from the opposite strand of the PEX5L gene locus on human chromosome 3. As an antisense RNA, it does not code for a protein but is thought to regulate gene expression either of PEX5L (Peroxisomal biogenesis factor 5 like) or potentially other genes, likely through mechanisms common to antisense lncRNAs such as chromatin remodeling, RNA interference, or modulation of epigenetic marks. PEX5L-AS2 is catalogued in genomic databases (NCBI Gene: 100505598; Ensembl: ENSG00000244302), but there is currently no published functional characterization, implication in specific diseases, or interactions with therapeutics. The PEX5L-AS2 transcript is primarily referenced in gene expression and co-expression studies, and there is no evidence to suggest it acts as a classical therapeutic target (such as an enzyme, receptor, or transporter).

Other names
PEX5L-AS2PEX5L antisense RNA 2 (non-protein coding)
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Mechanism of action

Not applicable; no known drugs interact directly with PEX5L-AS2

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Biological functions

Regulation of gene expressionEpigenetic regulation (potential, inferred by function of antisense lncRNAs)Possibly functions in cis or trans regulation of neighboring/proximal genes
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Disease associations

Currently, no specific role in disease has been well established for PEX5L-AS2Other antisense lncRNAs are implicated broadly in cancer and other diseases, but not specifically for PEX5L-AS2
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Safety considerations

None known
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Interacting drugs

None reported
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Biomarkers

None established

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