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Target intelligence / Profile preview
PGM5 antisense RNA 1 (PGM5-AS1)
- Target
- PGM5-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
PGM5 antisense RNA 1 (PGM5-AS1) is a human long non-coding RNA gene located on chromosome 9 (reverse strand)[1]. It belongs to the lncRNA class and acts as an antisense RNA relative to the protein-coding gene PGM5. Evidence indicates that PGM5-AS1 may function as a tumor suppressor, particularly in colorectal cancer, where its reduced expression is associated with increased tumor cell growth and proliferation in cellular and animal models. Conversely, higher PGM5-AS1 levels have sometimes been associated with poor prognosis, suggesting complex, context-dependent roles in cancer progression. It is being investigated as a potential prognostic biomarker for some cancer types, but there are no current therapeutic drugs targeting PGM5-AS1 or clinical safety concerns described in the literature[2][4][5][9].
- Other names
- FAM233ALOC572558family with sequence similarity 233 member APGM5-AS1 (non-protein coding)
02
Biological functions
Tumor suppression (evidence for suppressive role in colorectal cancer and esophageal squamous cell carcinoma)Regulation of cell proliferation and growthInteraction with microRNAs (such as miR-466)
03
Disease associations
Cancer (especially colorectal cancer, bladder cancer, esophageal squamous cell carcinoma)
04
Biomarkers
Prognostic biomarker for cancer, especially colorectal cancer
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