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PGM5P4 antisense RNA 1 (PGM5P4-AS1)
- Target
- PGM5P4-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other
01
Overview
PGM5P4 antisense RNA 1 (PGM5P4-AS1) is a long non-coding RNA (lncRNA) with a length of 950 base pairs, transcribed in an antisense orientation relative to the PGM5P4 gene. It acts as a tumor suppressor in various cancers; notably, it is downregulated in lung, liver, rectal, and breast cancers. Overexpression of PGM5P4-AS1 can inhibit cancer cell proliferation, migration, and invasion, and can suppress tumor growth in vivo. Mechanistically, PGM5P4-AS1 functions as a ceRNA (competing endogenous RNA), binding miR-1275 and promoting LZTS3 expression, which has anti-cancer activity. It is implicated as a potential biomarker for cancer diagnosis, prognosis, and may have future therapeutic utility[1][2][3].
- Other names
- FAM233Cfamily with sequence similarity 233 member CPGM5P4-AS1
02
Mechanism of action
Acts as a molecular sponge for microRNA miR-1275, thereby up-regulating the tumor suppressor gene LZTS3[1]
03
Biological functions
Regulation of cell proliferationRegulation of migrationRegulation of invasionApoptosisTumor suppressionOther
04
Disease associations
Cancer, including lung cancer, hepatocellular carcinoma, breast cancer, rectal adenocarcinoma, gallbladder cancer
05
Biomarkers
Downregulated levels are associated with several cancers; proposed as a biomarker for diagnosis and prognosis in lung, liver, rectal, and breast cancers[1]
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