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Target intelligence / Profile preview
PH and SEC7 domain-containing protein 1 (PSD)
- Target
- PSD
- Molecular classification
- Guanine nucleotide exchange factor, Other
01
Overview
PH and SEC7 domain-containing protein 1 (PSD) is a protein characterized by the presence of a pleckstrin homology (PH) domain and a SEC7 domain, functioning as a guanine nucleotide exchange factor (GEF) specifically for ARF6, a member of the ADP-ribosylation factor family of small GTPases. The protein plays key roles in regulating cytoskeletal dynamics, membrane trafficking, and neuronal development, such as axon growth and branching, by mediating guanine nucleotide exchange on ARF6. Given these cellular roles, PSD may contribute to neuronal morphogenesis and signaling, and genetic evidence suggests involvement in susceptibility to autism.
- Other names
- EFA6EFA6AExchange factor for ARF6KIAA2011PSD1TYLExchange factor for ADP-ribosylation factor guanine nucleotide factor 6Exchange factor for ARF6 APleckstrin homology and SEC7 domain-containing protein 1pleckstrin-Sec7 domains-containing
02
Biological functions
Regulation of ARF6 activityCytoskeletal remodelingRegulation of axon growth and branching
03
Disease associations
Neurodevelopmental disorders (evidence for susceptibility gene for autism)Potential roles in neurodegeneration or neural function (context from axon branching and cytoskeletal regulation)
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