Target intelligence / Profile preview

Acid–base homeostasis

Molecular classification
Other (complex physiological process, not a molecular entity)
01

Overview

Acid–base homeostasis is the process by which the body maintains the pH of extracellular fluid within a narrow range (typically arterial pH 7.36–7.44) essential for cell metabolism and organ function. This homeostasis is achieved through three complementary systems: chemical buffers (primarily the bicarbonate buffer), respiratory regulation (altering carbon dioxide excretion), and renal regulation (reabsorption/generation of bicarbonate, acid excretion). Disturbances in acid–base homeostasis result in metabolic or respiratory acidosis or alkalosis, which can have life-threatening consequences. Note: "Acid–base homeostasis" is a physiological process, not a discrete molecular target (such as a protein or receptor), so the requested structure is not applicable.

Other names
Acid–base balancepH regulationAcid-base equilibrium
02

Biological functions

Regulation of extracellular fluid pHMaintenance of cell metabolism and functionBuffering of acids and bases
03

Disease associations

Metabolic acidosisMetabolic alkalosisRenal insufficiencyRespiratory failureOsteoporosis (bone density loss from chronic acidosis)Nephrolithiasis (kidney stones)
04

Safety considerations

Not a target, but disturbances may cause severe clinical effects such as cardiac dysrhythmia, CNS depression, seizures, etc.
05

Biomarkers

Arterial blood pHPartial pressure of carbon dioxide (pCO2)Serum bicarbonate (HCO3-)Serum base excess

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