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Phagocytic Receptors on Myeloid Cells (N/A)

Target: N/A
Molecular classification: Receptor, Integrin, Pattern Recognition Receptor, C-type lectin, Immunoglobulin superfamily member

Overview

Phagocytic receptors are a diverse group of cell surface molecules expressed by myeloid cells (such as macrophages, neutrophils, monocytes, and dendritic cells) that mediate the recognition and internalization (phagocytosis) of pathogens, apoptotic cells, and other particulate targets. These receptors play a central role in innate immunity by enabling myeloid cells to clear infections and cellular debris.

Other names: Complement ReceptorsFc Gamma Receptors (FcγRs)Pattern Recognition Receptors (PRRs)Toll-like receptors (TLRs)Scavenger receptorsC-type lectinsIntegrinsPhosphatidylserine receptorsTREM2MerTKMARCOCR1 (CD35)CR3 (CD11b/CD18; Mac-1)CR4VSIG4FcγRI (CD64)FcγRIIA/B/C (CD32)FcγRIII (CD16)

Mechanism of action

N/A

Biological functions

PhagocytosisOpsonophagocytosisAntibody-dependent phagocytosisPathogen recognitionClearance of debrisClearance of apoptotic cellsImmune responseSignal transductionAntigen presentation

Disease associations

InfectionInflammationAutoimmune diseasesCancer (related to tumor microenvironment and immune evasion)

Safety considerations

Off-target effects on other cell typesPotential for exacerbating inflammatory responsesModulation of adaptive immunity

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