Phagocytosis

Phagocytosis is a cellular process in which cells (especially specialized immune cells called phagocytes, such as macrophages, neutrophils, dendritic cells, and some protists) ingest and eliminate large particles, including microorganisms, cell debris, and apoptotic bodies[1][2][5][6]. The process involves multiple steps: detection and binding of the target via cell-surface receptors, engulfment by plasma membrane extension to form a phagosome, subsequent fusion with lysosomes to form a phagolysosome where degradation occurs, and finally expulsion of residual material[1][2][4][5][6]. While central to the immune response and tissue maintenance, phagocytosis is a process rather than a druggable target itself, though certain molecules involved in phagocytosis (such as Fc gamma receptors and complement receptors) can serve as targets[2][4][6]. If more specificity is required, such as a particular phagocytic receptor or cell type (e.g., "Fc gamma receptor" or "macrophage mannose receptor"), those should be defined as targets instead.

Other names

phagocytic processcellular ingestion