Phagosomal membrane of antigen-presenting cells

The phagosomal membrane of antigen-presenting cells (APCs), such as macrophages and dendritic cells, is a dynamic lipid bilayer that forms around ingested particles during phagocytosis [Savina & Amigorena, 2007, Immunol Rev]. It serves as a critical platform for the innate and adaptive immune responses, facilitating the degradation of pathogens and the subsequent processing of antigens for presentation on MHC molecules [Guermonprez et al., 2002, Nature]. The membrane contains various proteins, including proton pumps (V-ATPases) for acidification, NADPH oxidase for reactive oxygen species production, and Toll-like receptors (TLRs) for pathogen recognition [Flannagan et al., 2009, Nat Rev Microbiol]. While not a single molecular target, the phagosomal membrane and its associated processes are focal points for therapeutic intervention in infectious diseases, where pathogens like Mycobacterium tuberculosis evade destruction by manipulating membrane fusion [Russell, 2001, Nat Rev Mol Cell Biol]. Additionally, modulating phagosomal functions, such as pH or maturation rate, is a strategy in cancer immunotherapy to enhance the cross-presentation of tumor antigens to CD8+ T cells [Joffre et al., 2012, Nat Rev Immunol]. Drugs like chloroquine interact with this compartment by neutralizing its acidic environment, thereby affecting antigen processing and viral entry [Savarino et al., 2003, Lancet Infect Dis].

Other names

Phagosome membranePhagocytic vacuole membraneAPC phagosomal membrane

Modulation of phagosomal pH and inhibition of phagosome-lysosome fusion