PHD finger protein 19 (PHF19)

PHF19 (PHD finger protein 19) is a polycomb group protein and chromatin modifier characterized by a Tudor domain, two PHD fingers, and an extended homologous (EH) domain[1][2]. As a reader of methylated histone marks, especially H3K36me3 and H3K27me3, PHF19 recruits the Polycomb repressive complex 2 (PRC2), enhancing its methylation activity and facilitating the transition from transcriptionally active to repressed chromatin states. This function is crucial in embryonic stem cell self-renewal and lineage determination, as PHF19 mediates the deposition of repressive H3K27me3 marks by activating PRC2 and recruiting demethylases (e.g., KDM2B)[1][2]. PHF19 is implicated in diseases such as melanoma and rheumatoid arthritis, primarily through its role in gene silencing and cellular differentiation; aberrant PHF19 activity or expression has been associated with tumorigenesis and autoimmune pathogenesis[2]. While no drugs currently target PHF19 directly, its unique histone interaction surfaces have been structurally characterized, potentially enabling future inhibitor or chemical probe development[1].

Other names

PCL3hPCL3DKFZP727G051MTF2L1TDRD19BPolycomb-like protein 3polycomb-like 3tudor domain containing 19B

Not applicable