PHD finger protein 3 (PHF3)

PHD finger protein 3 (PHF3) is a nuclear transcription regulator containing a PHD finger domain, the SPOC domain, and other chromatin-interacting features[1][8]. PHF3 binds specifically to RNA polymerase II phosphorylated at serine-2 within its C-terminal domain (CTD), thus reading the CTD code during transcription elongation[1][2][6][8]. This interaction modulates transcriptional activity and mRNA decay, helping restrict premature neuronal gene expression in stem cells and enabling proper neuronal differentiation[1][2]. Loss or mutation of PHF3 is linked to increased stability and expression of neuronal transcripts, impaired neurogenesis, and has been correlated with certain cancers (glioblastoma) and neurodevelopmental disorders (autism)[2][4]. PHF3 is also associated with retinitis pigmentosa and cone-rod dystrophy[4]. No approved drugs directly target PHF3, though it is of interest for further research as a disease-linked transcriptional regulator.

Other names

PHD finger protein 3PHF3KIAA0244si:dkey-188i13.1phf3