PHD finger protein 6 (PHF6)

PHD finger protein 6 (PHF6) is a highly conserved nuclear protein containing two atypical PHD (plant homeodomain)-like zinc finger domains. It belongs to the chromatin-regulating protein family and is implicated in transcriptional regulation and chromatin remodeling, acting through protein–protein interactions, recognition of modified histones, and direct DNA binding. PHF6 regulates chromatin state to enable or restrict access of transcription factors, controls transcription of target genes, and plays critical roles in both hematopoietic stem/progenitor cell homeostasis and neuronal development. Germline mutations in PHF6 cause Börjeson–Forssman–Lehmann syndrome, an X-linked intellectual disability disorder, with additional roles identified as a tumor suppressor in various leukemias. Loss of PHF6 leads to increased genomic and phenotypic plasticity, contributing to malignancy and drug resistance[1][2][3][4][5][6][7].

Other names

CENP-31KIAA1823MGC14797PHD-like zinc finger proteincentromere protein 31BFLSBORJ