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Target intelligence / Profile preview
Phenol-soluble modulin alpha toxin (PSMα)
- Target
- PSMα
- Molecular classification
- Peptide toxin, Amphipathic α-helical peptide
01
Overview
Phenol-soluble modulins (PSMs) are a family of small, amphipathic, α-helical peptides produced by staphylococci. The PSMα subgroup consists of several closely related peptides (PSMα1–4). These toxins play critical roles in bacterial pathogenesis, including cell lysis, immune modulation, and biofilm dynamics. They function through direct membrane disruption, FPR2-mediated signaling, and surfactant action, making them important virulence factors, especially in CA-MRSA strains.
- Other names
- PSM alpha toxinPSMα1PSMα2PSMα3PSMα4
02
Mechanism of action
Direct membrane disruption, FPR2-mediated signaling, Surfactant action
03
Biological functions
Cell lysisImmune modulationChemotaxisCytokine productionBiofilm formationBiofilm dispersalVirulence factor
04
Disease associations
InfectionBacterial pathogenesisSepsis
05
Safety considerations
CytotoxicityInflammation
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