Target intelligence / Profile preview

Phenoxybenzamine (null)

Target: null
Molecular classification: Other (synthetic organic drug / small molecule), Alpha-adrenoceptor antagonist (functionally; not a receptor itself)

Overview

Phenoxybenzamine is a synthetic non-selective, irreversible alpha-adrenergic receptor antagonist (alpha blocker) that covalently binds to alpha-1 and alpha-2 adrenoceptors, leading to vasodilation and decreased blood pressure. It is primarily used in the management of hypertension and excessive sweating associated with pheochromocytoma, a catecholamine-secreting tumor, and less commonly for benign prostatic hypertrophy or certain bladder and pain syndromes. Its action is long-lasting due to irreversible receptor blockade. As a molecule, phenoxybenzamine is not a biological target but a drug that acts on biological targets.

Other names: DibenzylineDibenylinePBZPhenoxybenzamine hydrochloride

Mechanism of action

Irreversible alpha-adrenoceptor antagonism (blocks both alpha-1 and alpha-2 adrenergic receptors, preventing catecholamine binding and causing vasodilation)\nChemical sympathectomy (long-lasting sympathetic inhibition via receptor blockade)

Safety considerations

Orthostatic hypotensionReflex tachycardiaNasal congestionFatigue and drowsinessMiosis (pupil constriction)Gastrointestinal upsetContraindicated in patients with conditions aggravated by hypotension (e.g., severe heart or kidney disease)

Beyond the preview

Go deeper on Phenoxybenzamine (null).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Phenoxybenzamine (null).

Explore the full profile