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Target intelligence / Profile preview
Phenylalanine (Phe)
- Target
- Phe
- Molecular classification
- Amino Acid, Essential Amino Acid, Aromatic Amino Acid
01
Overview
Phenylalanine is an essential aromatic amino acid that serves as a building block for proteins and a precursor for several important biomolecules, including tyrosine, dopamine, norepinephrine, epinephrine, melanin, and phenethylamine. It plays a critical role in protein synthesis and neurotransmitter production. However, individuals with phenylketonuria (PKU) must strictly limit phenylalanine intake due to a deficiency in the enzyme phenylalanine hydroxylase, which can lead to toxic accumulation of phenylalanine and neurological damage.
- Other names
- L-phenylalanine(2S)-2-amino-3-phenylpropanoic acid3-Phenyl-L-alaninealpha-Amino-beta-phenylpropionic acid
02
Mechanism of action
N/A
03
Biological functions
Protein synthesisPrecursor to tyrosine, dopamine, norepinephrine, epinephrine, melanin, and phenethylamineNeuromodulation
04
Disease associations
Phenylketonuria (PKU)Skin disorders (e.g., vitiligo)Mood disordersNeurological disorders
05
Safety considerations
Contraindicated in phenylketonuria (PKU)Potential for neurotoxicity in PKU patientsPotential antidepressant effects need further investigation
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