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Target intelligence / Profile preview
Phenylalanine 4-hydroxylase (PAH)
- Target
- PAH
- Molecular classification
- Enzyme, Biopterin-dependent aromatic amino acid hydroxylase
01
Overview
Phenylalanine 4-hydroxylase (PAH) is an enzyme that catalyzes the conversion of L-phenylalanine to L-tyrosine. This reaction is a critical step in phenylalanine catabolism and is essential for preventing toxic accumulation of phenylalanine in the body. Deficiency or dysfunction in PAH leads to hyperphenylalaninemia or classic phenylketonuria (PKU).
- Other names
- PKUPKU1phe-4-monooxygenasephenylalanine 4-monooxygenasePHPKU proteinphe-monooxygenasemonooxigenasa fenilalalinicapheApheB
02
Mechanism of action
Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine, requiring tetrahydrobiopterin (BH₄) and molecular oxygen.
03
Biological functions
Conversion of L-phenylalanine to L-tyrosinePhenylalanine catabolism
04
Disease associations
Phenylketonuria (PKU)HyperphenylalaninemiaNeurodevelopmental disorders
05
Safety considerations
Elevated phenylalanine levels can cause severe neurodevelopmental disorders if untreated in PKU patients.
06
Biomarkers
Phenylalanine levels in blood
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